The NEA is the first-ever UK educational institution that is specifically dedicated to enterprise and entrepreneurship and will expose students to real-life business environments.
Centres have been opened in Buckinghamshire and Manchester and the courses are open to 16-19 year olds.
It is planned that over 18,000 learners will be enrolled in the first five years of the institution, which has received £9m of investment from the government's Department for Business, Innovation and Skills.
"There is arguably no better time to create a National Enterprise Academy than during a recession.
"While it's true that traditional business studies courses equip students with a wealth of valuable theoretical business knowledge, there is currently no single academic course wholly dedicated to enterprise and entrepreneurship - a fact that inspired me to set about establishing the National Enterprise Academy," said Peter Jones, entrepreneur and founder of the NEA.
"There is arguably no better time to create a National Enterprise Academy than during a recession. The UK needs entrepreneurs to stimulate the economy and businesses need inspired employees to help their companies recover quickly."
The two new qualifications have a strong focus on practical skills. The first, a level 2 BTEC Diploma in Understanding Enterprise and Entrepreneurship, and the second, a level 3 BTEC Diploma in Enterprise and Entrepreneurship, have been developed in partnership with Edexcel, the UK's largest qualifications awarding body.